SiVance Divinyltetramethyldisilazane (CAS No. 7691-02-3) is a reactive silylamine containing silicon vinyl functional groups.
Divinyltetramethyldisilazane is used as a blocking agent of active hydrogen sites such as alcohols, thiols, amines and carboxylic acids during the synthesis of various pharmaceutic products. The advantage of this reagent is that the only by-product is ammonia which often can be readily removed from the reaction medium. Reactions can then be carried out elsewhere in a molecule. Vinyldimethylsilyl blocked sites are more stable towards acids than trimethylsilyl blocked sites, but have similar stability towards bases. The blocked site can later be regenerated by exposure to water or low molecular weight alcohols under mild acidic or basic conditions. Divinyltetramethyldisilazane is also used in the synthesis of vinylsilane terminated polydimethylsiloxanes.